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Título: Supercritical Biocatalysis

Palestrante: Pedro Lozano - Departamento de Bioquímica y Biología Molecular “B” e Inmunología. Facultad de Química. Universidad de Murcia - Spain

Horário: 11:00

Local: Anfiteatro do Instituto de Química

Data: 27 de novembro de 2019 (quarta-feira)




The development of sustainable chemical processes turns around two main axes: the selectivity of catalytic transformations, and the easy and clean separation of pure products. The technological utility of enzymes can be greatly enhanced by using them in non-conventional media, because their additional advantages (i.e. enhanced solubility of hydrophobic substrates, shift of thermodynamic equilibrium to flavor synthetic processes, etc.). However, volatile organic solvent has an important detrimental impact on the environment and human health, being necessary to develop green and clean reaction media before scaling-up processes with industrial interest.1-4

The classical advantages of supercritical carbon dioxide (scCO2) to extract, dissolve and transport chemicals are tarnished by the denaturative effect it has on enzymes. On the other hand, ILs have shown themselves to be excellent non-aqueous environments for enzyme catalysis. Biphasic systems based on ILs and scCO2 have been applied to develop green bioprocesses in non-aqueous media, where both the biocatalytic and extraction steps are coupled in environmentally benign and efficient reaction/separation processes in different kind of reactors (e.g. DKR of rac-1-phenylethanol, synthesis of biodiesel, etc.) 5-7


  1. P. Lozano et al, Chem. Commun., 2015, 51, 17361-173741.
  2. P. Lozano, Chem. Commum., 2002, 692-693
  3. P. Lozano et al., Green Chem., 2010, 12, 1803-1810
  4. E. García-Verdugo et al. Green Chem. 2015, 17, 2693-2713
  5. 4. P. Lozano et al. ChemSusChem, 2012, 5, 790-798.
  6. P. Lozano et al. Curr. Org. Synth. 2011, 8, 810-823
  7. 7. R. Villa et al., Green Chem., 2019, in press.


Professor Pedro Lozano received his BSc/MSc in Sciences (Chemistry) from the University of Murcia in June 1984, and his PhD in Sciences (Chemistry) from the University of Murcia in July 1988. Between, 1990 and 1991, he spent two years of post-doctoral formation at the Centre de Bioingénierie Gilbert Durand, Toulouse (France). In 1993, he returned to the Faculty of Chemistry at the University of Murcia (Spain) as Lecturer in Biochemistry and Molecular Biology, being finally promoted to Full Professor in 2004. Between 1996-2014, he was Assistant Dean of the Faculty of Chemistry and coordinator of the Biochemistry Degree at the University of Murcia, and since 2014 he is the Dean of the same Faculty. Prof. Lozano has also been Visiting Professor at the Universities of Rennes-France (2002) and Bordeaux-France (2013). His research activity has always been related with enzyme technology under non-conventional media, being focused on the use of biocatalysts ionic liquids and supercritical fluids for developing green chemical processes. He is the author of more than 140 publications (i.e. research papers, reviews, book chapters, etc), and more than 200 scientific Congress contributions. Prof Lozano was obtained the 7th IQS-European Award on Enzyme Technology (2003), and the Fellow position at the Royal Society of Chemistry (2017). Prof. Lozano is regional editor of the journal Current Green Chemistry, as well as member of the advisory board of Molecules and Mini-Reviews in Organic Chemistry journals.